Mariana Delgadinho

ORCID 
CIENCIAVITAE
mariana.delgadinho@estesl.ipl.pt

PhD Candidate

Research Topics

  • Molecular Biology
  • Genomics
  • Epigenetics
  • Microbiome
  • Sickle Cell Disease

Academic Degrees

PhD (ongoing):
Gut Microbiome Analysis in Patients with Sickle Cell Disease
Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa

Master:
Molecular and Cellular Biology
Characterization of the selective potential for the improvement of Cry toxins with nematicidal activity
Universidade de Aveiro
2017

Graduation:
Biotechnology
ESAC/IPC
2014

Scientific Projects

  • ParasitSCD: Detecting gut microbial pathogens in Angolan children with sickle cell disease. IDI&CA-IPL 2022-2023
  • miRCa: Identification of microRNAs modulators of fetal hemoglobin in cells exposed to Carica papaya extracts. IDI&CA-IPL 2022-2023
  • EpiCa: Effects of Carica papaya extracts in epigenetic, transcriptional and post-transcriptional regulation of fetal hemoglobin. New therapeutic target for hemoglobinopathies. IDI&CA-IPL 2022-2023
  • MICROCOVID19: Characterization of microbiotic profile in patients with COVID-19. Potential severity risk score and therapeutic targets
  • ScaffoldChild – Sickle Cell Anemia and Fetal Hemoglobin. Genetic modifiers in an Angolan Children Cohort. Aga Khan / FCT 2019-2020
  • HemoFet – Natural compounds potential for reactivation of γ-globin gene expression and Fetal Hemoglobin induction (In vitro approach). IDI&CA-IPL 2019-2020
  • SCDVOCbiom – Vaso-occlusion and Hydroxyurea in Sickle Cell Disease: Adhesion Molecules as Biomarkers. IDI&CA-IPL 2020-2021

Selected Papers

  • Delgadinho M, Ginete C, Santos B, et al. How Hydroxyurea Alters the Gut Microbiome: A Longitudinal Study Involving Angolan Children with Sickle Cell Anemia (2022). International Journal of Molecular Sciences; 23(16):9061. https://doi.org/10.3390/ijms23169061 
  • Delgadinho M, Ginete C, Santos B, et al. Microbial Gut Evaluation in an Angolan Pediatric Population with Sickle Cell Disease (2022). Journal of cellular and molecular medicine;1-23. https://doi.org/10.1111/jcmm.17402  
  • Germano I, Santos B, Delgadinho M, et al (2022). Genetic modulation of anemia severity, hemolysis level, and hospitalization rate in Angolan children with Sickle Cell Anemia. Mol Biol Rep; https://doi.org/10.1007/s11033-022-07831-1
  • Zeferino AS, Mira AR, Delgadinho M, Brito M, Ponte T, Ribeiro E (2022). Drug resistance and epigenetic modulatory potential of epigallocatechin-3-gallate against Staphylococcus aureus. Curr Microbiol;79(5):149. https://doi.org/10.1007/s00284-022-02841-5
  • Ribeiro E, Delgadinho M, Matos E, Santos R, Sousa D, Galante H, Brito M (2022). Epigenetic and Transcriptional Modulator Potential of Epigallocatechin-3-gallate and Genistein on Fetal Hemoglobin Reactivators Genes”. Clinical Complementary Medicine and Pharmacology: 100034. http://dx.doi.org/10.1016/j.ccmp.2022.100034
  • Delgadinho M, Ginete C, Santos B, Miranda A, Brito M (2021). Genotypic Diversity among Angolan Children with Sickle Cell Anemia. Int J Environ Res Public Health, 18, 5417. https://doi.org/10.3390/ijerph18105417
  • Santos B, Delgadinho M, Ferreira J et al (2020). Co-Inheritance of Alpha-Thalassemia and Sickle Cell Disease in a Cohort of Angolan Pediatric Patients. Mol Biol Rep. https://doi.org/10.1007/s11033-020-05628-8
  • Ribeiro E, Delgadinho M, Brito M (2019). Environmentally Relevant Concentrations of Bisphenol A Interact with Doxorubicin Transcriptional Effects in Human Cell Lines. Toxics, 7, 43. https://doi.org/10.3390/toxics7030043